Virulent form of H1N1 isolated from swine herds

A recent abstract appearing in PubMed highights a recent study on a virulent form of H1N1 virus (KS07) isolated from swine herds in the midwest. The virus is similar to an H1N1 virus that infected humans and pigs in Ohio in 2007. Pigs are known reservoirs of H1N1 viruses, and the study advocates for continued surveillance of influenza in swine. The study will be published in the journal Virus Genes.

Identification and characterization of a highly virulent triple reassortant H1N1 swine influenza virus in the United States. Virus Genes:2009 October 28.

Ma W, Vincent AL, Lager KM, Janke BH, Henry SC, Rowland RR, Hesse RA, Richt JA.
Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA, 50010, USA.

A highly virulent H1N1 influenza A virus, A/Swine/Kansas/77778/2007 (KS07), which caused approximately 10% mortality in finishing pigs, was isolated from herds in the Midwestern United States. Molecular and phylogenic analysis revealed this swine isolate was a triple reassortant virus, similar to an H1N1 virus that infected humans and pigs at an Ohio county fair in August 2007. A pig challenge model was developed to evaluate the pathogenicity and transmission capacity of the KS07 virus. The results confirmed that the KS07 virus is highly virulent in pigs and easily transmitted to sentinel animals. The KS07 virus failed to cross-react with a panel of H1-specific swine sera. Interestingly, the KS07 virus shed for a prolonged period up to 7 days in infected pigs, indicating that this virus can spread efficiently between animals. The highly virulent H1N1 swine influenza virus is further evidence of reassortment among avian, human and swine influenza viruses and justifies the need for continued surveillance of influenza viruses in swine.

PMID: 19862613 [PubMed – as supplied by publisher]

PubMed is a free resource that is developed and maintained by the National Center for Biotechnology Information (NCBI), at the U.S. National Library of Medicine (NLM), located at the National Institutes of Health (NIH).

Life Extension - Health And Medical Findings

PubMed: Identification and characterization of a highly virulent triple reassortant H1N1 swine influenza virus in the United States.
Virology Journal: Interspecies and intraspecies transmission of triple reassortant H3N2 influenza A viruses

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