H1N1 Transitions: Three New H1N1 Variants Detected in India

ProMed mail reports on three new H1N1 variants detected by India’s National Institute of Virology (NIV). All the variants were treatable with the antiviral medication Oseltamivir (Tamiflu). Excerpt and references provided below:

Archive Number 20100525.1741
Published Date 25-MAY-2010
Subject PRO/AH Influenza pandemic (H1N1) (34): Indian variants
A ProMED-mail post


ProMED-mail is a program of the
International Society for Infectious Diseases


Date: Tue 25 May 2010
Source: The Times of India, Pune [edited]


The National Institute of Virology (NIV) here has detected 3 new
variants of the H1N1 virus. Fortunately, all 3 variants have shown
susceptibility to Tamiflu, the drug used in the treatment of swine
flu. However, with the virus actively acquiring new properties, NIV
scientists are apprehensive that it might develop resistance to the
medicines used in treating swine flu. “For now, there is no need to
worry. But we are closely monitoring the virus for any change in its
virulence,” NIV assistant director Sarah Cherian told the Times of
India recently.

Cherian said 7 mutated variants of the virus have been found across
the world so far. “As expected of the seasonal influenza virus, the
H1N1 virus is also going through constant genetic variations which
might lead to significant changes in its antiviral resistance,” she

The variants of the H1N1 virus, representing both recovered and fatal
cases from major cities — Pune, Mumbai, Delhi, Hyderabad and
Bangalore — were analysed at the NIV, and the complete genomes of
these variants were sequenced. The results of the genetic analysis
have been published in the March 2010 issue of the US journal, PLOS

Read the remainder of the article at ProMed Mail

Communicated by:
ProMED-mail Rapporteur Mary Marshall

[The detection of 3 genetic variants circulating in India is an
interesting observation. For the benefit of readers wishing more
precise detail, the abstract of the PLoS ONE paper is posted below.

“Title: Genetic Characterization of the Influenza A Pandemic (H1N1)
2009 Virus Isolates from India. Reference: PLoS ONE 5(3): e9693.

By: Varsha A. Potdar, Mandeep S. Chadha, Santosh M. Jadhav, Jayati
Mullick, Sarah S. Cherian, Akhilesh C. Mishra At: National Institute
of Virology, Pune, India.


PLoS ONE: Genetic Characterization of the Influenza A Pandemic (H1N1) 2009 Virus Isolates from India. Reference: PLoS ONE 5(3): e9693.
Times of India: Pune, 25 May 2010


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